increases the chance of a healthy birth per embryo transfer.
The best-in-class accuracy of PGT[A]Seq means an increased number of euploid embryos are correctly reported, leading to more viable embryos being transferred with higher pregnancy rates than is achieved using less accurate PGT-A methods.
More embryos are reported ‘euploid’ using PGT[A]Seq compared to some other PGT-A methods
Unlike most other methods, PGT[A]Seq combines two distinct pieces of information to provide unparalleled accuracy. The test simultaneously assesses the quantity of DNA at thousands of sites on each chromosome using an advanced next generation sequencing method. The test also evaluates numerous variations in the DNA sequence, known as single nucleotide polymorphisms (SNPs). Together, these two pieces of information provide major advantages over other PGT-A methods, including the detection of triploid embryos. The PGT[A]Seq technology is the most accurate test of its kind, with proven clinical validity.
- The most powerful embryo selection tool
- The most accurate and highly validated test of its kind
PGT[A]Seq method provides two pieces of information:
Quantity of DNA measured at thousands of individual sites
Genotypes determined for thousands of DNA polymorphisms
- Avoid unsuccessful transfer of non-viable aneuploid embryos
- Reduced miscarriage rate
- Reduced risk of aneuploid syndromes
- Faster time to pregnancy
- Permits high efficiency single embryo transfer (SET)
- Accurate detection of triploidy
- Avoids incorrect 'mosaic' designation
- Higher proportion of embryos classified 'euploid'
The most powerful and accurate embryo analysis on the market
Juno uses a unique PGT[A]Seq methodology, which has successfully demonstrated clinical validity in a non-selectin study
Our PGT[A]Seq technique employs the latest next-generation sequencing methods, increasing the quality of the data obtained and yielding results of unparalleled accuracy
All couples undergoing IVF have a high likelihood that some of their embryos will be aneuploid. Such embryos typically fail to implant, miscarry, or more rarely produce abnormal pregnancies affected by problems such as Down syndrome. Consequently, PGT[A]Seq is likely to have value for all couples. However, testing chromosomes in embryos becomes progressively more important as women age. By the age of 35 it is typical for more than one-third of embryos to be aneuploid, and by the time a woman is over 40, more than three-quarters of embryos are chromosomally abnormal.
PGT[A]Seq results are typically available 6 days after Juno receives the embryo biopsy samples (although results can take up to 10 days).
We aim to make working with Juno Genetics as easy as possible. Juno is committed to supporting the clinics it works with, providing guidance at all stages of the PGT process. We are available seven days a week to assist with queries or to provide advice. At Juno we appreciate that different clinics may have unique needs and our policy is one of flexibility, where we adapt to the specific requirements of each clinic. If your clinic already offers PGT in collaboration with another genetics laboratory, then it is likely that very few significant changes, if any, will be necessary. Please contact Juno Genetics and we will be happy to walk you through the enrolment procedure, provide all necessary documentation and answer any questions you might have. If your clinic is new to PGT, Juno can help by providing valuable information and documentation to get you started. Juno can also assist with training and evaluation of procedures, making sure that all elements of the PGT procedure are optimised and working well, prior to the launch of a clinical service. Please contact firstname.lastname@example.org to begin working with Juno.
If the proportion of samples that fail to give a PGT result is consistently higher than expected, this is almost always due to a problem with technique used for the cell washing and loading or, less commonly, with the embryo biopsy method. Scientists at Juno Genetics have decades of experience working with clinics in order to achieve optimal PGT results and can assist with troubleshooting. Problems are almost always solved after simple and easy to implement changes to procedure.